When work safety is not carried out properly, unwanted incidents will occur. If that happens, the achievement of work targets will be delayed because it can reduce the results of employee performance which was originally maximum to a minimum due to a lack of employee awareness in an effort to protect themselves. The author conducted a study to determine the relationship of compliance, work safety, and employee performance in the General Affairs and Purchasing section of PT Indonesia Synthetic Textile Mills Tangerang. This research uses quantitative descriptive analysis writing. From data processing it was found that the relationship between Employee Compliance (X1) and Employee Performance (Y1), the authors concluded that the X1 and Y1 variables had a moderate relationship. Meanwhile, the relationship between Safety Efforts (X2) and Employee Performance (Y1) shows a number of 0.880. That is, between the variables X2 and Y1 have a strong relationship.